Among the 180
infertile males, 43 were non-obstructive azoospermics and 137 were
oligozoospermics. They all were examined for chromosomal alterations by GTG
karyotyping method. The frequency and types of chromosomal aberrations found in
infertile males are summarized in table I, II, III & IV. Major chromosomal
abnormalities found in infertile males was 16.3% (7/43) in azoospermics and
9.5% (13/137) in oligozoospermics with an overall 11.2% (20/180) in infertile
males (Table 1).

            In total 20 (11.2%) cases of
abnormalities, numerical abnormalities found in 6 (3.3%) in which 4 (9.3%) were
in azoospermics and 2 (1.4%) were in oligozoospermics while structural
abnormalities found in 14 (7.7%) in which 3 (6.9%) were in azoospermics and 11
(8%) were in oligozoospemics (Table II).

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            All 6 numerical abnormalities were
Klinefelter’s syndrome; 4 were with classic pattern 47,XXY karyotype and 2 were
with mosaic forms of 47XXY86/46,XY14 pattern. However, out of 14 cases of
structural abnormalities; 7 were autosomal translocations, 3 inversions, 2
deletions and 2 cases had of supernumerary marker chromosomes (sSMC). No major
chromosomal abnormality was found in control group (P<0.05).             Polymorphic chromosomal variants were found in 56 infertile males (31.2%), this incidence was similar to that in 21 fertile men (35%) from the control group (P>0.05).  Autosomal chromosomal variants were observed
more frequently than sex chromosomal variants. Alterations in the
heterochromatin region of the chromosome 9 were the most frequently identified
polymorphism in 16 (8.8%) infertile males; 5 (11.6%) men in azoospermics and 11
(8%) in severe oligozoospermics. 
Polymorphic variants were also found in chromosome 1 (n=27), chromosome
16 (n=8), Y chromosome (n=10) and in acrocentric chromosome 14, 21 and 22
called satellites (Table 4).