Cardiovasculardisease (CVD) is a class of diseases involving heart or bloodvessels. 1 Cardiovasculardiseases account for more deaths worldwide than any other disease. It resulted in 17.9 milliondeaths (32.
1%) in 2015, up from 12.3 million (25.8%) in 1990.2Obesity is a major riskfactors for a number of chronic diseases, including cardiovascular diseases.other risk factors includes hypertension, dyslipidaemia and impaired glucosetolerance/insulin resistance.3Vitamin D is afat-soluble vitamin that functions as a steroid hormone and It has been recognized as a vitamin which isessential for bone–mineral health.
In the past two decades, numerousexperimental and observational studies have highlighted the role of vitamin Din immunity, metabolic syndrome (obesity and diabetes), cancers, renal disease,memory, and neurological dysfunction.4 Furthermore, studies have suggested a potential role of25-hydroxyvitamin D (25-OH-D), the major circulating form of vitamin D, in decreasing risk of cardiovascular diseases (CVD)5Although the underlying biological causes are not fullyunderstood, the link between Vitamin Dand cardiovascular pathology is speculated to be driven by various mechanisms: maybe it is due to potential direct impact on cardiomyocytes and myocardialdiseases, it has been suggested that 25-OH-D indirectly modifies CVD risk byits association with cardiovascular risk factors like obesity, diabetes,hypertension, smoking, or cholesterol level. However, vitamin D physiology and dosage may differaccording to body weight. individualswith obesity require higher doses of vitamin D in order to improve theirvitamin D status compared to subjects with normal weight 6Hypovitaminosis Dis linked with the cardiovascular disease 7A meta-analysis is theneed of the hour in evaluating role of vitamin D and cardiovascular diseases.particularly in obese individuals.