countries, people more rely on herbal based medicine for primary health care. In
recent years, herbal medicine and their active components are gaining
popularity to encounter various metabolic diseases such as obesity, heart disease
and diabetes etc., (Butt et al 2009).
In generally believe that herbal medicines are natural, no toxic or side effects
and immensely contribute to health benefits (Adeyemi et al 2014).
sativum, commonly known as garlic is one of the ancient medicinal
herbs and most heavily studied herbs over the past several decades and the report
is mostly good. Garlic holds a unique
active substance which contributes to wide range of pharmacological effect including
anti hyperlipidemic effect (Majewski,
2014). There is evidence that hypolipidemic influences of garlic shows
significantly reduce serum and hepatic total cholesterol, triglyceride, and
low-density lipoprotein levels and increase serum high-density lipoprotein
levels (Niaz et al, 2016; Uday Singh et
Cow ghee or
clarified butter from milk solid could be consumed as food and as medicine. It
contains high energy, essential fatty acids and fat soluble vitamins (Ganguli and Jain 1973). Cow ghee is a traditional
medicine in Ayurveda and which are practiced for thousands of years, apart from
its role in the daily use of culinary purposes and traditional religious rituals.
Cow’s ghee holds numerous medicinal properties and many of its combinations
with herbs are described in traditional texts. Karandikar et al 2016; Shukla and Tripathi 2006; Murthy Srikantha et al
1998). Despite this fact, ghee contains higher amount saturated fatty acids
which causes cardiovascular risks were reported. Evidence on the health effects
of ghee and garlic are individually reported by Indian system of medicine,
which discusses the possible benefits. However, there is no scientific data has
been made in regard to the hypolidemic of garlic and its combination with ghee.
These spurt interest to develop a dietary intervention of Garlic infused ghee to
explore their synergistic therapeutic effects in rodent model.
In the past
decades, hyperlipidemia and associated complications have reached epidemic proportions.
For the study of this pathophysiology, several rodent models have been
developed. High-fat diet model is the one to induced obesity in rodent by high
calorie intervention method. The word ‘high fat diet’ is first introduced by Masek
& Fabry in 1959. These animal models enhance the increase glycemic
index and insulin resistances on both muscle and liver. Based on this
observation, high-fat diets can be used to valuable tool to rodent model for
the metabolic syndrome (Buettner et al 2006).
Therefore, present study was undertaken to ascertain whether the combination of
both garlic and ghee produces synergistic effect in hyperlipidemic condition.