It system in the ventral striatum (Juckel et al.,

It was originally
thought that psychosis was the main consequence of aberrant salience, however
recent discoveries have reported that negative symptoms may arise due to the
overstimulation of irrelevant stimuli. Taking this into account, research into
non-medicated patients using fMRI scans of the brain found that reduced
activation in the ventral-striatal caused individuals to respond to irrelevant
stimuli, leading to both high risk psychosis, and negative symptoms. This suggests
that individuals may become less interested in relevant stimuli over time due
to interference in the processing of the reward system in the ventral striatum
(Juckel et al., 2006). Therefore, the literature indicates that aberrant
salience contributes to the presence of both positive and negative symptoms in
schizophrenics.