One of the most valuable components of indigenous medical systems forover 40 centuries has been Mangifera indicaleaves, the largest fruit-bearing tree ever discovered in India. Theusage of Mangifera indica leaves as amedicinal agent dates back to as early as 327 BCE.The presence of some major groups of phytochemical constituents such assaponins, anthraquinones, terpenoids, etc.
and therapeutically activecomponents such as mangiferin,stigmasterol, friedelin, lupeol, etc. havealso been reported from Mangifera indica leaves. There is a scarcity of scientific information in support of theirsuccess, whilst the leaves have been traditionally used as an antibacterial and immunomodulatory agent. Mangifera indicaleaves are also used as an antibacterial agent in Nigerian folk herbalism. To ascertain whether or not there isa scientific basis for this use, theeffect of the blood glucose level was evaluated innormoglycaemic, glucose-induced hyperglycaemic and streptozotocin (STZ) induced diabetic rodents such as Rattus (rat).
The aqueous extract given orally did not modify the blood glucose levels ineither normoglycaemic or STZ-induced (streptozotocin) diabetic rodentsspecifically Rattus (rat). Aqueous extracts of Mangifera indica leaves showed remarkable influence on reproductive functions,wound regeneration and antidiabetic tasks. Alcoholic extracts of Mangiferaindica leaves have been found containing TNF- (Tumor necrosis factor), ILIBexpression and B-lactamase producing entericbacterial development.
Mangifera indica leaves are equipped witha broad outer cuticle to avoid the loss of nutrientsand to prevent wetting when it’sraining. Furthermore, Mangifera indicaleaves are found alternating on the plant stalk to exploit the light energy acquired from the sun. This is because of thefact that Mangifera indica develops best when exposed to sunlight.